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Elysium Health

Signal

Signal

$60.00 USD
$60.00 USD
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Power up the powerhouse of your cells. Signal is designed to target metabolic aging by protecting mitochondria—where the energy in your cells is made. Increase NAD+ with the precursor NMN to support energy production and activate SIRT3, a key mitochondrial enzyme, to protect and generate new mitochondria and help your cells adapt to daily metabolic changes as you age.

  • Increase levels of the critical coenzyme NAD+ by 40% via the highly efficient precursor NMN
  • Activate sirtuin 3 (SIRT3) to protect and generate new mitochondria to support cellular metabolism and energy
  • Help maintain healthy insulin sensitivity in muscle—essential to maintaining blood sugar levels
  • Support vascular health—critical for your athletic endurance 
  • Support brown fat thermogenesis, a cellular process which converts sugar and fat into heat to help maintain body temperature and support a healthy metabolism
  • Reduce general tiredness and fatigue, support healthy muscle function, and feel good for your age
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    Your Metabolism Ages Too

    Metabolism converts food into the energy you need for life. As you age, your metabolism slows and becomes less efficient—impacting how quickly and effectively your cells function. 

    This happens for two main reasons: First, levels of a coenzyme called NAD+, which is central to hundreds of metabolic processes and cellular energy production, decline. Second, enzymes inside our mitochondria—the powerhouses of our cells—like SIRT3 that depend on NAD+ to function slow down.

    See the science

    Matter Slows Brain Atrophy

    What causes this brain loss? Research has shown that having lots of the amino acid homocysteine in the blood is correlated with brain atrophy in healthy older adults.

    The good news? Homocysteine levels respond to the availability of B vitamins. This is where Matter comes in. To unlock the benefits of B vitamins for brain health, Matter contains a tri-vitamin complex that was developed with Oxford and is clinically proven and patented to slow the brain volume loss that happens as we age. Doctors and world-renowned researchers recommend Matter for long-term brain health.

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    “Signal is a novel, mitochondria-centric product formulated to counter aging-dependent declines in metabolism by promoting youthful energetics and metabolic efficiency.”

    Leonard Guarente, Ph.D.,Elysium founder, chief scientist, and renowned aging researcher and professor

    Activating SIRT3 to Support Mitochondrial Health

    Matter is a breakthrough in consumer health and contains: A tri-vitamin complex developed with Oxford clinically proven to slow brain atrophy, a next-generation, EPA and DHA omega-3 in powder form that is 4x more readily absorbed than standard fish oils, and a special antioxidant: bilberry anthocyanins. 

    Harnessing the Oxford findings, each element in Matter’s formulation was selected for performance and quality, and specially dosed for efficacy. Matter is third-party tested by independent labs both during and after manufacture for purity and quality, and is independently verified as NSF Certified for Sport.

    Basis 101: The Science

    • What is nicotinamide mononucleotide (NMN)?

      NMN is a safe and efficient precursor to NAD+, the essential coenzyme and key metabolite found in every cell of the human body, and invol...

    • NMN and NR: How These NAD+ Precursors Measure Up

      NR is a highly efficient precursor to NAD+, but its cousin molecule NMN is raising eyebrows as the new kid on the block.

    • How to Choose an NMN Supplement

      NMN supplements contain the molecule nicotinamide mononucleotide, a precursor to NAD+ that shows promise in supporting multiple aspects o...

    Frequently Asked Questions

    What is Signal and what does it do?

    Signal is designed to target metabolic aging at the cellular level by increasing NAD+ levels, which decline with age, and by activating processes that support mitochondrial health

    How is Signal different from Basis?

    Signal is designed to promote metabolic health, while Basis targets overall cellular aging and DNA maintenance. Both provide NAD+ precursors — Signal contains NMN, Basis contains NR. Signal activates SIRT3 (mitochondrial health). Basis activates SIRT1 (gene expression and DNA maintenance). Early evidence suggests possible tissue-specific differences between NMN and NR, though more research is needed.

    I’m already taking Basis, why should I take Signal as well?

    Preclinical evidence suggests varied tissue-specific benefits between NMN and NR. Taking both may help elevate NAD+ across a broader range of tissues. Signal targets mitochondrial function, while Basis targets gene regulation and DNA maintenance. Together they provide a more comprehensive approach to cellular and metabolic aging.

    What is SIRT3 and what are the potential benefits of activating it?

    SIRT3 is a NAD+-dependent enzyme located in mitochondria. It supports mitochondrial health and metabolic control including glucose metabolism, ATP production, fatty acid oxidation, ketone production, and amino acid cycling. As mitochondrial function declines with age, Signal is designed to activate SIRT3 to promote metabolic and mitochondrial health.

    What is NMN?

    NMN (nicotinamide mononucleotide) is the immediate precursor to NAD+. It is involved in over 500 cellular reactions. NMN converts efficiently to NAD+ with minimal energy steps, making it an effective NAD+ precursor.

    What is metabolic aging?

    Metabolic aging is the dysregulation of metabolism that occurs with age. NAD+ and sirtuin levels decline, disrupting metabolic balance and energy regulation. Signal is designed to restore balance by increasing NAD+ and activating SIRT3.

    Can I take Signal alongside my other Elysium supplements?

    Yes. All Elysium supplements can be taken together. No known interactions have been identified, but consultation with a physician is recommended for health-related concerns.